• Thermal Ionization MS

    The Inductively Coupled Plasma A plasma is a hot, partially ionized gas. The ICP is an argon-based, radio frequency plasma.The ICP is an argon-based, radio frequency plasma. The input rf frequency is either 27 or 40 MHz at powers from 1 to 2 kW. The plasma is formed and contained in a three tube The plasma is formed and contained in a three tube

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  • Thermal Ionization Mass Spectrometry (TIMS) | Wiley Online ...

     · In addition to thermal ionization mass spectrometry (TIMS), he also discusses applications of ICP-MS. Furthermore, alongside detailed protocols on sample preparation and mass spectrometric measurements, numerous practical hints are given. A must-have handy guide for all isotope geochemists and anyone involved in isotope analysis. ...

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  • Mass Spectrometry Ionization Methods

    Another similar ionization technique is to spray a surface with the ESI spray and have the spray extract ions from the surface into the mass spectrometer. This technique is called desorption electrospray ionization (DESI) and produces spectra similar to electrospray, but is analyzing the sample on a surface.

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  • Materials and Fuels Complex

    The ion source housing chamber is evacuated and the filaments are heated under controlled conditions to promote volatilization and ionization of the sample. The ionized analyte is then directed through an accelerating section of the instrument and into a magnetic analyzing sector of the mass spectrometer …

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  • PRACTICAL APPLICATION OF THERMAL IONIZATION MASS ...

    To provide the level of measurement sensitivity necessary to meet this monitoring requirement, Los Alamos National Laboratory (LANL) developed an ultra-sensitive analytical procedure through the application of thermal ionization mass spectrometry (TIMS) for determination of plutonium-239/240 in urine samples [2].

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  • Fusion method for sample preparation for isotopic ...

    Direct fusion technique for determination of 10 B/ 11 B ratio in refractory materials by Thermal ionization Mass Spectrometry.. The samples were fused with sodium carbonate directly on the filament for formation of Na 2 BO 2 +.. Validation of the direct fusion technique by analyses of dissolved samples and boron purified by solvent extraction.

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  • Improved sample utilization in thermal ionization mass ...

     · @article{osti_1356166, title = {Improved sample utilization in thermal ionization mass spectrometry isotope ratio measurements: refined development of porous ion emitters for nuclear forensic applications}, author = {Baruzzini, Matthew Louis}, abstractNote = {The precise and accurate determination of isotopic composition in nuclear forensic samples is vital for assessing origin, intended …

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  • Finnigan MAT 262 TIMS | SIGMA Facility

    Finnigan MAT 262 TIMS. The Thermal Ionization Mass Spectrometer is used for high-precision isotope ratio measurements. Thermal Ionization Mass Spectrometry (TIMS) is used for very precise isotope ratio measurements. Purified samples are thermally ionized by passing a current through a thin metal filament (or filaments). Mass resolved ion beams ...

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  • Radiochemistry Webinars

    trouble-shooting sample preparation and mass spectrometry analyses, and quantifying sources of uncertainty in mass spectrometry measurements. Dr. Rebecca Thomas is a mass spectrometrist at the Department of Energy''s New Brunswick Laboratory (NBL), which is the United States'' certification authority for nuclear reference materials.

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  • Gas Chromatography – Mass Spectrometry (GC MS)

    A GC-MS experiment begins with sample preparation, injection and separation on a GC column (as discussed in the previous article). Since the operation of a mass spectrometer requires a high-vacuum system, an interface is necessary to direct the molecules from the GC to the mass spectrometer.

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  • Improved Sample Loading for Plutonium Analysis by Thermal ...

    Thermal ionization mass spectrometry (TIMS) and alpha spectroscopy are ... TIMS sample loading. Substrate preparation involved forming ultrathin films (10-180 nm) of quaternary amine anion-exchange polymers on glass and silicon by dip-coating.

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  • Direct Sample Analysis Using a Thermal Extraction ...

    Direct Sample Analysis Using a Thermal Extraction Ionization Source (TEIS) Combined with Mass Spectrometry Technical Features and Attributes of the TEIS with a SCIEX QTRAP® System Pierre Negri1, Carl 2M.Fletcher, Richard Sleeman2, Peter Luke2, Neil Davenport3 and Ashley Sage3 1SCIEX, US; 2Mass Spec Analytical Ltd, UK; 3SCIEX, UK Mass Spectrometry (MS) is a widely used …

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  • Amazon : Thermal Ionization Mass Spectrometry (TIMS ...

    In addition to thermal ionization mass spectrometry (TIMS), he also discusses applications of ICP-MS. Furthermore, alongside detailed protocols on sample preparation and mass spectrometric measurements, numerous practical hints are given. A must-have handy guide for all isotope geochemists and anyone involved in isotope analysis.

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  • "Alternative Sample Loading Preparation for Thermal ...

    This contribution describes a new sample loading method for Thermal Ionization Mass Spectrometry (TIMS), which is used in nuclear safeguards and non-proliferation efforts worldwide and is known as the "gold standard" in isotopic ratio measurements of plutonium. TIMS analysis is used to determine grades of nuclear material and the extent of enrichment at production sites.

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  • Thermal Ionization Mass Spectrometry – Excelic Press

    ISBN:9781642241891 Contributors: Biswaranjan Paital, Teodor Octavian Nicolescu Format: Hardcover Year: 2019 Pages: 366 Availability: In Stock

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  • Thermal Ionization Mass Spectrometers

    Thermal Ionization Mass Spectrometers Putting samples in the Triton mass spectrometer This facility''s two Thermo-Finnigan Triton Thermal Ionization Mass Spectrometers (aka TIMS) have capabilities for high precision isotopic and elemental abundance measurements of Sr, Nd, Sm, Ca, K, Fe, U, Th, Pb, Ba, La, Ce, Cr and limited Rb, using ...

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  • sample preparation

    Thermo Scientific Pierce Products for Mass Spectrometry Sample Preparation Introduction 1-5 Introduction 1 Sample Lysis and Protein Extraction 6-11 Introduction 6 ... into the mass spectrometer (e.g., electrospray ionization or ESI) as they elute from a C18 reversed-phase HPLC column. As peptides elute, the mass

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  • Thermal Ionization Mass Spectrometry Facility, John de ...

     · Thermal Ionization Mass Spectrometry Facility. The Thermal Ionisation Mass Spectrometry Facility (TIMS) provides highly accurate and precise measurements of the isotopic composition of elements using TIMS TritonTM instrument, including sample preparation in clean contamination-free environment.

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  • GC-MS Sample Preparation | Thermo Fisher Scientific

    Sample preparation methods for GC-MS. Gas chromatography mass spectrometry (GC-MS) sample preparation is performed on smaller and more volatile samples including environmental pollutants, industrial byproducts, food contaminants, pesticides, and metabolites of illicit and designer drugs. These molecules are more challenging to ionize and ...

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  • Sample Preparation for Probe Electrospray Ionization Mass ...

     · International Journal of Mass Spectrometry and Ion Processes. 78, 53-68 (1987). Tanaka, K., et al. Protein and polymer analyses up to m/z 100000 by laser ionization time-of flight mass spectrometry. Rapid Communications in Mass Spectrometry. 2, 151-153 (1988).

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  • Akio Makishima: Thermal ionization mass spectrometry (TIMS ...

     · The book Thermal ionization mass spectrometry (TIMS): silicate digestion, separation, and measurement by Akio Makishima discusses the entire process required to perform isotopic analyses by TIMS, including descriptions of initial sample digestion techniques for a variety of environmental and geological matrices, detailing chemical separations ...

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  • 87Sr STRONTIUM ANALYSIS BY THERMAL IONIZATION …

    MASS SPECTROMETRY Sample Preparation: Strontium concentration data for any submitted sample is crucial in order to decide the required sample weight or volume. Thermal Ionization Mass Spectroscopy (TIMS) can be used to analyze only a few micrograms of strontium (25 to ...

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  • Thermal Ionization Mass Spectrometry (TIMS)

     · Fundamental Principles of Thermal Ionization Mass Spectrometry (TIMS) A TIMS is a magnetic sector mass spectrometer that is capable of making very precise measurements of isotope ratios of elements that can be ionized thermally, usually by passing a current through a thin metal ribbon or ribbons under vacuum. The ions created on the ribbon (s ...

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  • Sample Preparation for Mass Spectrometry | Thermo Fisher ...

    Downloadable Thermo Scientific Protein Sample Preparation and Quantitation for Mass Spectrometry Handbook about tools and techniques for more robust and reproducible sample processing, protein quantitation and instrument calibration ... Venter AR (2013) Protein analysis by desorption electrospray ionization mass spectrometry and related methods ...

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  • CHAPTER 4 Signal Processing Methods for Mass …

    For large biological molecules with low volatility and thermal instability you ... Ionization Mass Spectrometry (SELDI-MS). These methods can detect high molec-ular mass, low volatile, and thermally liable compounds such as proteins in bio- ... 4.1.3 Sample Preparation Electrospray (ESI) does not need any prior sample preparation. Sample ...

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  • Extraction Chromatographic Methods in the Sample ...

     · A sample preparation sequence for actinide isotopic analysis by thermal ionization mass spectrometry (TIMS) is described that includes column-based extraction chromatography as the first separation step, followed by anion-exchange column separations. The sequence is designed to include a wet ashing step after the extraction chromatography to prevent any leached extractant or …

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  • Thermal Ionization Mass Spectrometry (TIMS): Silicate ...

    In addition to thermal ionization mass spectrometry (TIMS), he also discusses applications of ICP-MS. Furthermore, alongside detailed protocols on sample preparation and mass spectrometric measurements, numerous practical hints are given. A must-have handy guide for all isotope geochemists and anyone involved in isotope analysis.

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  • Sample preparation in mass spectrometry

     · Fundamental Principles of Thermal Ionization Mass Spectrometry (TIMS) A TIMS is a magnetic sector mass spectrometer that is capable of making very precise measurements of isotope ratios of elements that can be ionized thermally, usually by passing a current through a thin metal ribbon or ribbons under vacuum. The ions created on the ribbon (s ...

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  • Sample preparation in mass spectrometry and similar topics ...

    Form of ionization in which ions are formed in an ion source outside the mass spectrometer without sample preparation or separation. Ions can be formed by extraction into charged electrospray droplets, thermally desorbed and ionized by chemical ionization, or laser desorbed or ablated and post-ionized before they enter the mass spectrometer.

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  • Mass Spectrometry Tutorial (Dr. Kamel Harrata) | Chemical ...

    Matrix Assisted Laser Desorption (MALDI) mass spectrometry technique was introduced by Karas and Hillkamp in 1988 for the ionization of peptides and proteins. Soon there after this technique was able to analyze other type of biomolecules, such as oligosaccharides, glycolipids, nucleotides, and …

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  • Sample Preparation | Harvard Center for Mass Spectrometry

    Call us at (617) 384-9585 if you have any questions regarding sample preparation. As a rule of thumb, avoid the use of detergents (especially non-ionic detergents), nonvolatile salts, TFA (>0.10%) and other additives. A table of salts and buffers which are incompatible with mass spectrometry and their levels is downloadable below.

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  • Thermal Ionization Mass Spectrometry

    Thermal Ionization Mass Spectrometry. TIMS remains the isotopic analysis technique of choice for nuclear materials analysis, particularly for small samples (sub-picogram to nanogram) of uranium and plutonium which are loaded either as a solution residue, or on a resin bead, that is vaporized and ionized at a heated filament surface from which the ions are extracted and analyzed.

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  • Ionization source for mass spectrometer

    View the video "APCI LDTD Ionization Source for Mass Spectrometer" by WynSep: Once the sample is introduced into Lazwell 96 or 384 wells, the 1 to 2 μl of solvent are …

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